I don't think you understand how the game works ping, it's designed for a pad. It's over the shoulder 3rd person. The gameplay in general is quite slow, enemies are sluggish, so you have time to move and aim around. Watch some youtube vids.
Mouse and keyboard is generally better for this type of game but it was ported to the PC from console, it was designed around a gamepad. It doesn't have any real settings for mouse smoothing and speed.
@Jango40: I know very well how these games work and I can assure you that using m+kb is not a problem (and in fact it never is, but besides that, it's not a problem for resi4 in particular).